Genetic and genomic studies have identified genes and gene variants that may impact the fundamental biological mechanisms underpinning substance use disorders (SUDs).
Discovery of these genes/variants, while extremely valuable, is only the first step in understanding the molecular processes that
influence SUDs.
This Funding Opportunity Announcement (FOA) encourages basic functional genetic and genomic research in two areas:
1. functional validation to determine which candidate genes/variants/epigenetic/non-coding RNA features have an authentic role in SUDs, and 2. detailed elucidation of the molecular pathways and processes modulated by candidate genes/variants, particularly for those genes with an unanticipated role in SUDs.