Purpose.

This Funding Opportunity Announcement (FOA) issued by the National Cancer Institute (NCI), National Institutes of Health (NIH), solicits grant applications proposing exceptionally innovative, high risk, original and/or unconventional research projects focused on evaluating the performance

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of emerging, potentially transformative molecular and cellular analysis technologies within the context of an appropriate cancer-relevant biological system.

The emphasis of this FOA is on the application of emerging molecular and cellular analysis tools with the potential to (i) create new or challenge existing scientific and technological paradigms and/or (ii) overcome technological barriers in important areas of cancer research.

Projects must clearly demonstrate potential to produce a major impact in a broad area of biomedical or cancer-relevant research through application to a relevant biological system.

This funding opportunity is part of a broader NCI-sponsored Innovative Molecular Analysis Technologies (IMAT) Program.

Several IMAT FOAs of identical or closely related scientific scope using various funding mechanisms are available.

To facilitate selection, a separate Notice in the NIH Guide for Grants and Contracts provides brief cross-comparison and links to all the IMAT FOAs.

See NOT-CA-09-00 7.