The purpose of this Funding Opportunity Announcement (FOA) is to support research on human immunodeficiency virus (HIV)-associated cancers in low- and middle-income countries (LMICs) through the formation of collaborative partnerships between investigators in United States (U.S.) and investigators in

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LMICs.

The FOA solicits applications for Specialized Center Cooperative Agreements (U54) for research on HIV-associated cancers from research institutions in the U. S. and LMICs.

These partnerships are referred to as HIV-Associated Malignancy Research Centers (HAMRCs).

Each proposed U54 HAMRC should be based upon partnerships involving at least one U. S. institution and institutions from at least two or more LMICs.

Each HAMRC application is required to propose between two to three research projects that address questions in one scientific theme (e.g.

viral-associated cancers) that is relevant to HIV-associated malignancies in LMICs or the U. S. The proposed projects may range, as appropriate, from basic research to translational efforts as well as to population and implementation studies.

Mechanistic clinical studies that meet NIH's definition of a clinical trial will be allowed.

In addition, the proposed U54 HAMRC must include an Administrative Core and a Developmental Core.