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Limited Competition for Data Coordinating Center (DCC) for NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) (U24)
The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) was established in July, 2002 for the purpose of identifying genes predisposing to IBD.
Since its establishment, the IBDGC, in collaboration with the International IBD Genetics Consortium, has identified about 200 such susceptibility
loci.
However, most of these loci include multiple genes, and for the great majority of the loci, specific casual genes and alleles have not yet been identified.
The mechanisms by which the most of the causative genes influence IBD pathophysiology also remain unknown.
The purpose of this FOA is to renew the IBDGC to identify risk-conferring and protective variants of causal genes for IBD, and to elucidate the mechanisms by which these variants influence the pathophysiology of IBD.
The DCC will coordinate collaboration among the Genetic Research Centers (GRCs, described in the companion FOA RFA-DK-16-029), enrollment of subjects into the study, submission of blood and other biological samples to centralized repositories, processing of blood samples for extraction of DNA and isolation of cells and serum, submission of clinical, genetic, and molecular data to central databases, and analyses of data, and manage the operations of the Steering Committee and other operational committees.
The DCC will also coordinate the development of pilot projects for rapid follow-up of emerging findings by members of the IBDGC and external collaborators.
In addition, the DCC will coordinate the collaboration of the IBDGC with the International IBDGC, and with other external investigators conducting ancillary studies.
The PD/PI of the DCC shall serve as a voting member of the Steering Committee of the IBDGC, and be bound by all of the operational decisions of this Committee.
Since its establishment, the IBDGC, in collaboration with the International IBD Genetics Consortium, has identified about 200 such susceptibility
loci.
However, most of these loci include multiple genes, and for the great majority of the loci, specific casual genes and alleles have not yet been identified.
The mechanisms by which the most of the causative genes influence IBD pathophysiology also remain unknown.
The purpose of this FOA is to renew the IBDGC to identify risk-conferring and protective variants of causal genes for IBD, and to elucidate the mechanisms by which these variants influence the pathophysiology of IBD.
The DCC will coordinate collaboration among the Genetic Research Centers (GRCs, described in the companion FOA RFA-DK-16-029), enrollment of subjects into the study, submission of blood and other biological samples to centralized repositories, processing of blood samples for extraction of DNA and isolation of cells and serum, submission of clinical, genetic, and molecular data to central databases, and analyses of data, and manage the operations of the Steering Committee and other operational committees.
The DCC will also coordinate the development of pilot projects for rapid follow-up of emerging findings by members of the IBDGC and external collaborators.
In addition, the DCC will coordinate the collaboration of the IBDGC with the International IBDGC, and with other external investigators conducting ancillary studies.
The PD/PI of the DCC shall serve as a voting member of the Steering Committee of the IBDGC, and be bound by all of the operational decisions of this Committee.
Related Programs
Diabetes, Digestive, and Kidney Diseases Extramural Research
Department of Health and Human Services
Agency: Department of Health and Human Services
Office: National Institutes of Health
Estimated Funding: $1,476,000
Office: National Institutes of Health
Estimated Funding: $1,476,000
Who's Eligible
Relevant Nonprofit Program Categories
Obtain Full Opportunity Text:
http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-16-510.html
Additional Information of Eligibility:
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U. S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U. S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Full Opportunity Web Address:
http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-16-510.html
Contact:
NIH OER WebmasterFBOWebmaster@OD.NIH.GOV
Agency Email Description:
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster
Agency Email:
FBOWebmaster@OD.NIH.GOV
Date Posted:
2016-08-17
Application Due Date:
2016-12-14
Archive Date:
2017-01-14
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