Limited Competition for the Continuation of the Diabetes Prevention Program Outcomes Study (DPPOS) Clinical Centers (Collaborative U01 Clinical Trial Required)

The purpose of this Limited Competition Funding Opportunity Announcement (FOA) is to continue follow-up of the Diabetes Prevention Program Outcomes Study (DPPOS) cohort through a collaborative cooperative agreement.

The Diabetes Prevention Program (DPP) was a multi-center controlled clinical trial

examining the efficacy of treatments to prevent or delay the development of type 2 diabetes in a population at high risk.

The DPP demonstrated that either weight loss through lifestyle change or the drug metformin could reduce the development of type 2 diabetes by 58% and 31%, respectively, compared with placebo.

Following the end of DPP, the DPP cohort was enrolled in the DPPOS to determine the long-term effects of the DPP interventions on further diabetes development and microvascular complications.

The current funding period is focused on examining the effectiveness of early metformin treatment on the development of cancer and cardiovascular disease.

The DPPOS study population has aged, and there is an opportunity to study the heterogeneity in chronic disease development and progression in this well-characterized, diverse study population.

The primary purpose of this FOA is to support the DPPOS clinical centers to maintain follow-up the DPPOS cohort to continue to explore contributors to the development of multiple chronic conditions, including, but not limited to, cognitive impairment, cancer, and diabetes vascular complications, and to evaluate whether the DPP interventions have any preventive effect on the development of these chronic conditions.

RFA-DK-20-502 will support continuation of the DPPOS Biostatistics Research Center.
Related Programs

Cancer Cause and Prevention Research

Department of Health and Human Services


Diabetes, Digestive, and Kidney Diseases Extramural Research

Department of Health and Human Services


Aging Research

Department of Health and Human Services


Agency: Department of Health and Human Services

Office: National Institutes of Health

Estimated Funding: $1,200,000


Who's Eligible





Obtain Full Opportunity Text:
http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-20-501.html

Additional Information of Eligibility:
Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.

Non-domestic (non-U.S.) components of U. S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

See RFA for full eligibility

Full Opportunity Web Address:
http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-20-501.html

Contact:


Agency Email Description:
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

Agency Email:


Date Posted:
2020-01-23

Application Due Date:


Archive Date:
2020-05-28


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