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DoD Ovarian Cancer Investigator-Initiated Research Award
The OCRP Investigator-Initiated Research Award is intended to support high-impact research that has the potential to make an important contribution to ovarian cancer or patient/survivor care.
Research projects may focus on any phase of research, from basic laboratory research through translational
research, excluding clinical trials.
The application must demonstrate logical reasoning and a sound scientific rationale established through a critical review and analysis of the literature for the application to be competitive.
Applications must include preliminary data that are relevant to ovarian cancer and support the proposed research project.
The proposed research must be relevant to active duty Service members, Veterans, military beneficiaries, and/or the American public.
The anticipated direct costs budgeted for the entire period of performance for an FY18 OCRP Investigator-Initiated Research Award will not exceed $450,00 0. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.
All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of preclinical research.
The standards are described in Landis, S.C., et al., A call for transparent reporting to optimize the predictive value of preclinical research, Nature 2012, 490:187-19 1. Research involving cell lines, animal models, human subjects, and human anatomical substances is permitted; however, this award may not be used to conduct clinical trials.
Information on clinical trials and phases/classes of study is provided in the “Human Subject Resource Document” available for download from eBRAP at https://ebrap.org/eBRAP/public/ Program.htm.
A clinical trial is defined as a prospective accrual of patients (human subjects) in whom an intervention (e.g., device, drug, biologic, surgical procedure, rehabilitative modality, behavioral intervention, or other) is tested for a measurable outcome with respect to safety, effectiveness, and/or efficacy.
This outcome represents a direct effect on the subject of that intervention or interaction.
Research Involving Human Anatomical Substances, Human Subjects, or Human Cadavers:
All DoD-funded research involving new and ongoing research with human anatomical substances, human subjects, or human cadavers must be reviewed and approved by the U. S. Army Medical Research and Materiel Command (USAMRMC) Office of Research Protections (ORP), Human Research Protection Office (HRPO), prior to research implementation.
This administrative review requirement is in addition to the local Institutional Review Board (IRB) or Ethics Committee (EC) review.
Local IRB/EC approval at the time of submission is not required.
The HRPO is mandated to comply with specific laws and requirements governing all research involving human anatomical substances, human subjects, or human cadavers that is supported by the DoD.
These laws and requirements will necessitate information in addition to that supplied to the IRB/EC.
Allow a minimum of 2 to 3 months for HRPO regulatory review and approval processes.
When possible, protocols should be written for research with human subjects and/or human anatomical substances that are specific to the DoD-supported effort outlined in the submitted application.
Submission to HRPO of protocols covering more than the scope of work in the DoD-funded award will require HRPO review of the entire protocol as DoD-supported research and may include extensive modifications to meet DoD human subjects protection requirements.
Refer to the General Application Instructions, Appendix 1, and the Human Subject Resource Document available on the electronic Biomedical Research Application Portal (eBRAP) “Funding Opportunities & Forms” web page (https://ebrap.org/eBRAP/public/Program.htm) for additional information.
Research Involving Animals:
All DoD-funded research involving new and ongoing research with animals must be reviewed and approved by the USAMRMC ORP Animal Care and Use Review Office (ACURO), in addition to the local Institutional Animal Care and Use Committee (IACUC) of record.
IACUC approval at the time of submission is not required.
Specific documents relating to the use of animals in the proposed research will be requested if the application is selected for funding.
The ACURO must review and approve all animal use prior to the start of working with animals, including amendments to ongoing projects.
PIs must submit the institutional animal use protocol, IACUC approval of that protocol, and a version of the animal use appendix titled “Research Involving Animals.” Allow at least 2 to 3 months for ACURO regulatory review and approval processes for animal studies.
Refer to the General Application Instructions, Appendix 1, for additional information.
The types of awards made under the Program Announcement will be assistance agreements (grants or cooperative agreements).
The level of involvement on the part of the Department of Defense (DoD) during project performance is the key factor in determining whether to award a grant or cooperative agreement.
Extramural Organizations:
An assistance agreement (grant or cooperative agreement) is appropriate when the Federal Government transfers a “thing of value” to a “state, local government,” or “other recipient” to carry out a public purpose of support or stimulation authorized by a law of the United States, instead of acquiring property or service for the direct benefit and use of the U. S. Government.
An assistance agreement can take the form of a grant or cooperative agreement.
If “no substantial involvement” on the part of the funding agency is anticipated, a grant award will be made (31 USC 6304).
Conversely, if substantial involvement on the part of the funding agency is anticipated, a cooperative agreement will be made (31 USC 6305) and the award will identify the specific substantial involvement.
Substantial involvement may include collaboration, participation, or intervention in the research to be performed under the award.
The award type, along with the start date, will be determined during the negotiation process.
The CDMRP intends that information, data, and research resources generated under awards funded by this Program Announcement be made available to the research community (which includes both scientific and consumer advocacy communities) and to the public at large.
For additional guidance, refer to the General Application Instructions, Appendix 2, Section K.
Awards will be made no later than September 30, 201 9. For additional information refer to Section II.F.1, Federal Award Notices.
Research projects may focus on any phase of research, from basic laboratory research through translational
research, excluding clinical trials.
The application must demonstrate logical reasoning and a sound scientific rationale established through a critical review and analysis of the literature for the application to be competitive.
Applications must include preliminary data that are relevant to ovarian cancer and support the proposed research project.
The proposed research must be relevant to active duty Service members, Veterans, military beneficiaries, and/or the American public.
The anticipated direct costs budgeted for the entire period of performance for an FY18 OCRP Investigator-Initiated Research Award will not exceed $450,00 0. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.
All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of preclinical research.
The standards are described in Landis, S.C., et al., A call for transparent reporting to optimize the predictive value of preclinical research, Nature 2012, 490:187-19 1. Research involving cell lines, animal models, human subjects, and human anatomical substances is permitted; however, this award may not be used to conduct clinical trials.
Information on clinical trials and phases/classes of study is provided in the “Human Subject Resource Document” available for download from eBRAP at https://ebrap.org/eBRAP/public/ Program.htm.
A clinical trial is defined as a prospective accrual of patients (human subjects) in whom an intervention (e.g., device, drug, biologic, surgical procedure, rehabilitative modality, behavioral intervention, or other) is tested for a measurable outcome with respect to safety, effectiveness, and/or efficacy.
This outcome represents a direct effect on the subject of that intervention or interaction.
Research Involving Human Anatomical Substances, Human Subjects, or Human Cadavers:
All DoD-funded research involving new and ongoing research with human anatomical substances, human subjects, or human cadavers must be reviewed and approved by the U. S. Army Medical Research and Materiel Command (USAMRMC) Office of Research Protections (ORP), Human Research Protection Office (HRPO), prior to research implementation.
This administrative review requirement is in addition to the local Institutional Review Board (IRB) or Ethics Committee (EC) review.
Local IRB/EC approval at the time of submission is not required.
The HRPO is mandated to comply with specific laws and requirements governing all research involving human anatomical substances, human subjects, or human cadavers that is supported by the DoD.
These laws and requirements will necessitate information in addition to that supplied to the IRB/EC.
Allow a minimum of 2 to 3 months for HRPO regulatory review and approval processes.
When possible, protocols should be written for research with human subjects and/or human anatomical substances that are specific to the DoD-supported effort outlined in the submitted application.
Submission to HRPO of protocols covering more than the scope of work in the DoD-funded award will require HRPO review of the entire protocol as DoD-supported research and may include extensive modifications to meet DoD human subjects protection requirements.
Refer to the General Application Instructions, Appendix 1, and the Human Subject Resource Document available on the electronic Biomedical Research Application Portal (eBRAP) “Funding Opportunities & Forms” web page (https://ebrap.org/eBRAP/public/Program.htm) for additional information.
Research Involving Animals:
All DoD-funded research involving new and ongoing research with animals must be reviewed and approved by the USAMRMC ORP Animal Care and Use Review Office (ACURO), in addition to the local Institutional Animal Care and Use Committee (IACUC) of record.
IACUC approval at the time of submission is not required.
Specific documents relating to the use of animals in the proposed research will be requested if the application is selected for funding.
The ACURO must review and approve all animal use prior to the start of working with animals, including amendments to ongoing projects.
PIs must submit the institutional animal use protocol, IACUC approval of that protocol, and a version of the animal use appendix titled “Research Involving Animals.” Allow at least 2 to 3 months for ACURO regulatory review and approval processes for animal studies.
Refer to the General Application Instructions, Appendix 1, for additional information.
The types of awards made under the Program Announcement will be assistance agreements (grants or cooperative agreements).
The level of involvement on the part of the Department of Defense (DoD) during project performance is the key factor in determining whether to award a grant or cooperative agreement.
Extramural Organizations:
An assistance agreement (grant or cooperative agreement) is appropriate when the Federal Government transfers a “thing of value” to a “state, local government,” or “other recipient” to carry out a public purpose of support or stimulation authorized by a law of the United States, instead of acquiring property or service for the direct benefit and use of the U. S. Government.
An assistance agreement can take the form of a grant or cooperative agreement.
If “no substantial involvement” on the part of the funding agency is anticipated, a grant award will be made (31 USC 6304).
Conversely, if substantial involvement on the part of the funding agency is anticipated, a cooperative agreement will be made (31 USC 6305) and the award will identify the specific substantial involvement.
Substantial involvement may include collaboration, participation, or intervention in the research to be performed under the award.
The award type, along with the start date, will be determined during the negotiation process.
The CDMRP intends that information, data, and research resources generated under awards funded by this Program Announcement be made available to the research community (which includes both scientific and consumer advocacy communities) and to the public at large.
For additional guidance, refer to the General Application Instructions, Appendix 2, Section K.
Awards will be made no later than September 30, 201 9. For additional information refer to Section II.F.1, Federal Award Notices.
Who's Eligible
Relevant Nonprofit Program Categories
Obtain Full Opportunity Text:
http://grants.nih.gov/grants/guide/pa-files/PA-18-753.html
Additional Information of Eligibility:
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U. S. Territory or Possession.
Full Opportunity Web Address:
http://grants.nih.gov/grants/guide/pa-files/PA-18-753.html
Contact:
Agency Email Description:
CDMRP Help Desk
Agency Email:
Date Posted:
2018-04-11
Application Due Date:
Archive Date:
2018-09-21
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