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Dermal Physiologically-Based Pharmacokinetic (PBPK) Models Accounting for the Absorption and Evaporation of Vehicle/Co-Solvent Following the Application of Generic Dermatological Products
The overall objective of this funding opportunity is to develop an enhanced mechanistic PBPK model for generic dermatological drug products by accounting for the absorption and evaporation of vehicle/co-solvent simultaneously and implementing the effect of these two dynamic processes on the permeation
of a drug molecule through skin.
The developed model will be utilized to inform decisions on generic dermatological product development, to enhance the understanding of the effect of metamorphosis of dermatological drug products on skin absorption, and to predict the local and systemic exposure of a drug molecule following topical application of dermatological drug products.
of a drug molecule through skin.
The developed model will be utilized to inform decisions on generic dermatological product development, to enhance the understanding of the effect of metamorphosis of dermatological drug products on skin absorption, and to predict the local and systemic exposure of a drug molecule following topical application of dermatological drug products.
Agency: Department of Health and Human Services
Office: Food and Drug Administration
Estimated Funding: $385,000
Office: Food and Drug Administration
Estimated Funding: $385,000
Who's Eligible
Obtain Full Opportunity Text:
http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-21-005.html
Additional Information of Eligibility:
Family Water Alliance
Full Opportunity Web Address:
http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-21-005.html
Contact:
Agency Email Description:
shashi.malhotra@fda.hhs.gov
Agency Email:
Date Posted:
2021-05-25
Application Due Date:
Archive Date:
2021-05-26
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