The purpose of this Notice of Funding Opportunity (NOFO) is to provide a funding mechanism for Emerging Infections Sentinel Networks (EISN) research activities, specifically within a network of emergency departments (EDs).

The EISN program will assist in operating emergency department provider-based

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sentinel networks.

These networks will contribute to surveillance for emerging infectious diseases (EID), such as those caused by agents of bioterrorism, pathogens of pandemic potential, drug-resistant, foodborne or waterborne microorganisms, and vaccine-preventable or potentially vaccine-preventable diseases (e.g., Bacillus anthracis.

new coronaviruses, Clostridium difficile, carbapenem-resistant Enterobacteriaceae, viral hepatitis and respiratory viruses of epidemic or pandemic potential, tuberculosis, sexually transmitted diseases), and help inform operational public health and healthcare decisions during public health emergencies (e.g., assessment of rapid screening and triage protocols during surge of infectious disease cases presenting for clinical care; assessment of clinical characteristics and development of rapid epidemiologic studies during emergencies to improve the understanding of the clinical characteristics, impacts and outcomes of new and emerging diseases), help better understand and address the disproportionate impact of EIDs on underserved and disadvantaged populations, and enhance information exchange.