This Funding Opportunity Announcement (FOA) solicits R21 grant applications to develop novel technologies that will enable substantive (no less than an order of magnitude) improvement in DNA sequencing, and practical methods for direct RNA sequencing.
Applicants may propose to develop novel complete
sequencing systems, investigate challenges underlying key novel system components, or propose improvements of at least an order of magnitude improvement to existing systems.
Exploration of methods other than those currently in use is highly encouraged.
High-risk/high-payoff applications are appropriate to achieve the goals of this FOA.