This Limited Competition Funding Opportunity Announcement (FOA) invites an application from the currently funded Microphysiological Systems (MPS) Database Center (MPS DC) which supports the NIH Tissue Chip Consortium.

The overall goal of the MPS DC is to integrate the efforts of all funded components

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of the Tissue Chip Consortium and serve as a community-wide resource for deposition of tissue chip data, standards, protocols, and analytical tools.

The MPS DC is expected to continue to be the central clearinghouse for tissue chips data management, and to incorporate novel approaches and technologies for data management, data mining and meta-analyses, and data sharing across many organs and tissues, diseases, data types, and tissue chip platforms.

The MPS DC is expected to provide different levels of public and tiered access to tissue chip information for basic and clinical researchers, academic and practicing physicians, the pharmaceutical industry, NIH, FDA and other government agencies, patients, and the lay public.

The MPS DC will work with IQ Consortium members to develop and make available a secure, customizable coordinated data management system for collection, storage, and analyses of diverse data types from multiple tissue chip platforms being developed and used for drug screening, safety and efficacy testing.

The application must include a clear and well laid out plan to be completely independent and self-sustaining before the end of the requested NIH support.