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Multi-Site Study of the Health Implications of Exposure to PFAS-Contaminated Drinking Water
The Agency for Toxic Substances and Disease Registry (ATSDR) is soliciting research to commence a multi-site study on the human health effects of exposures to drinking water contaminated with per- and polyfluoroalkyl substances (PFAS).
Proposed study sites must include communities using PFAS-contaminated
private residential wells or public water systems.
Exposure assessment will be based on measured PFAS serum levels as well as estimated PFAS serum levels derived from pharmacokinetic modeling of reconstructed PFAS drinking water concentrations over time.
Specifically, grant awardees will be required to conduct historical reconstruction/water modeling in order to determine the PFAS concentration.Effect biomarkers such as lipids and tests of immune and thyroid function derived from pharmacokinetic modeling of reconstructed PFAS drinking water concentrations over time will be evaluated.ATSDR intends this research to be a two-part program consisting of (1) a mandatory core research protocol to allow ATSDR to aggregate the core data and to compare laboratory and statistical analyses across sites, and (2) each successful awardee will have the option to propose additional investigator-initiated research questions and hypotheses related to the overall goals of this NOFO.
Proposed study sites must include communities using PFAS-contaminated
private residential wells or public water systems.
Exposure assessment will be based on measured PFAS serum levels as well as estimated PFAS serum levels derived from pharmacokinetic modeling of reconstructed PFAS drinking water concentrations over time.
Specifically, grant awardees will be required to conduct historical reconstruction/water modeling in order to determine the PFAS concentration.Effect biomarkers such as lipids and tests of immune and thyroid function derived from pharmacokinetic modeling of reconstructed PFAS drinking water concentrations over time will be evaluated.ATSDR intends this research to be a two-part program consisting of (1) a mandatory core research protocol to allow ATSDR to aggregate the core data and to compare laboratory and statistical analyses across sites, and (2) each successful awardee will have the option to propose additional investigator-initiated research questions and hypotheses related to the overall goals of this NOFO.
Related Programs
Environmental Public Health and Emergency Response
Department of Health and Human Services
Agency: Department of Health and Human Services
Office: Centers for Disease Control and Prevention - ERA
Estimated Funding: $32,500,000
Office: Centers for Disease Control and Prevention - ERA
Estimated Funding: $32,500,000
Who's Eligible
Relevant Nonprofit Program Categories
Obtain Full Opportunity Text:
Bureau of Educational and Cultural Affairs Organizational Funding Opportunities
Additional Information of Eligibility:
Please see full announcement.
Full Opportunity Web Address:
https://eca.state.gov/organizational-funding/open-grant-solicitations
Contact:
Agency Email Description:
Grants Policy
Agency Email:
Date Posted:
2019-04-01
Application Due Date:
Archive Date:
2019-07-03
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