The FY21 DMDRP Translational Research Award mechanism supports translational research that will accelerate the movement of promising ideas in DMD research into clinical applications.

Translational research may be defined as an integration of basic science and clinical observations.

Observations

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that drive a research idea may originate from a laboratory discovery, population-based studies, or a clinician’s firsthand knowledge of patient care.

The ultimate goal of translational research is to move a concept or observation forward into clinical application.

However, Principal Investigators (PIs) should not view translational research as a one-way continuum from bench to bedside.

The research plan must involve a reciprocal flow of ideas and information between basic and clinical science.This mechanism is intended to support established projects that have moved beyond the realm of basic research and have the potential to result in a near-term impact in clinical research or the clinic.

Research projects investigating therapies that will be efficacious across the life span, particularly in adolescents and adults are strongly encouraged.

Pilot, proof-of-principle clinical trials and correlative studies to better inform development of drugs, devices, and other interventions are allowed.

All applications must include preliminary data relevant to DMD and the proposed project.