Human Health Studies_Applied Research and Development

To solicit scientific proposals designed to answer public health questions arising from situations commonly encountered at hazardous waste sites.

The objective of this research program is to fill gaps in knowledge regarding human health effects of hazardous substances identified during the conduct
of ATSDR's health assessments, consultations, toxicological profiles, and health studies, including but not limited to those health conditions prioritized by ATSDR.

The ATSDR Priority Health Conditions are (in alphabetical order): (1) Birth defects and reproductive disorders; (2) cancers (selected anatomic sites); (3) immune function disorders; (4) kidney dysfunction; (5) Liver Dysfunction; (6) Lung and Respiratory Diseases; and (7) neurotoxin disorders.
Examples of Funded Projects

Funded projects include grants to State health departments and universities to conduct health studies that relate to hazardous substances and investigate health conditions prioritized by ATSDR.

Examples of funded projects are: 1.

A study to examine residential exposure to specific urban air toxicants through multiple pathways and indoor allergens in an urban area and their relationship to asthma prevalence and immune function using nested case- control study.


A study to probe the possible synergistic relationships between exposure to chemicals commonly found at hazardous waste sites and likely to contaminate the border area and maternal infections suspected to be risk factors for NTDs.

Agency - Department of Health and Human Services

The Department of Health and Human Services is the Federal government's principal agency for protecting the health of all Americans and providing essential human services, especially to those who are least able to help themselves.

Program Accomplishments

In fiscal year 2001, there were 8 new competitive awards and 3 non-competitive continuation awards. In fiscal year 2002, it is estimated there will be 12 new competitive awards and 11 non-competitive continuation awards. In fiscal year 2003, it is estimated there will be 20 non-competing continuation awards. In FY 2004 and FY 2005 efforts continued to support approximately 20 non-competing awards.

Uses and Use Restrictions

To strengthen the State governments, State colleges, State universities, State research institutions, federally-recognized Indian tribal governments, U. S. Territories and possessions to fill the gap in knowledge regarding the occurrence and risk factors for the Priority Health Conditions.

Eligibility Requirements

Applicant Eligibility

Eligible applicants are State health departments or their bona fide agents or instrumentalities.

This includes the District of Columbia, the Commonwealth of Puerto Rico, the Virgin Islands, Guam, the Federated States of Micronesia, the Republic of the Marshall Islands, the Republic of Palau, the Northern Mariana Islands, American Samoa, the political subdivisions thereof, which may include State universities, State colleges, and State research institutions, and federally-recognized Indian tribal governments.

Beneficiary Eligibility

The ultimate beneficiaries of this program are the Federal, State, local, other public institutions/organizations, federally-recognized Indian tribal governments, U.S. Territories/possessions, and the general public in their ability to address potential health problems related to environmental exposures and adverse health outcomes.


Costs will be determined in accordance with OMB Circular Nos. A-87, A-21, and A-122 as applicable.

Aplication and Award Process

Preapplication Coordination

No preapplication is required.

This program is eligible for coverage under E.O.

12372, "Intergovernmental Review of Federal Programs." An applicant should consult the office or official designated as the single point of contact in his or her State for more information on the process the State requires to be followed in applying for assistance, if the State has selected the program for review.

Application Procedures

Applicants must use application Form PHS 5161-1. Application packets are available from: Mildred Gardner, Grants Management Branch, Procurement and Grants Office, Centers for Disease Control and Prevention, 2920 Brandywine Road, Room 3000, Atlanta, GA 30341. By formal agreement, the CDC Grants Management Branch will act on behalf of ATSDR on this matter.

Award Procedures

The Assistant Administrator, ATSDR has final authority to approve funding of applications. When an application is approved for funding, the Grants Management Officer, CDC, acting as agent for ATSDR, will prepare a Notice of Grant Award.


Contact the Headquarters Office identified below for application deadlines.


Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980, as amended; Superfund Amendments and Reauthorization Act of 1986, Sections 104(i)(7), (9), and (15), Public Law 99-499; 42 U.S.C. 9604 (i)(7), (9), and (15).

Range of Approval/Disapproval Time

Approximately 60 to 90 days.




Awards are made for project periods of one to five years with 12-month budget periods. Renewal awards cannot be made beyond the project period without competition.

Assistance Considerations

Formula and Matching Requirements

This program has no statutory formula or matching requirements.

Length and Time Phasing of Assistance

The awards will be made for 12-month budget periods within a project period of 1 to 5 years. Continuation awards within the project period are made on the basis of satisfactory progress and availability of funds.

Post Assistance Requirements


Semi-Annual progress and financial status reports are required no later than 90 days after the end of each budget period.

Final financial status and performance reports are required 90 days after the end of the project period.


In accordance with the provisions of OMB Circular No. A- 133 (Revised, June 27, 2003), "Audits of States, Local Governments, and Nonprofit Organizations," nonfederal entities that expend financial assistance of $500,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Nonfederal entities that expend less than $500,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in Circular No. A-133. In addition, grants and cooperative agreements are subject to inspection and audits by DHHS and other Federal officials.


Detailed and accurate records of travel expenditures, personnel hours and all other costs will be retained for 10 years in accordance with EPA's "Superfund Financial Management and Recordkeeping Guidance for Federal Agencies." Such documents may be required to provide the basis of cost recovery actions or other litigation. Additionally, this documentation must be available for audit or verification upon the request of the Inspector General.

Financial Information

Account Identification



(Grants) FY 07 $155,874; FY 08 $0; and FY 09 est not available.

Range and Average of Financial Assistance

$50,000 to $500,000; $100,000.

Regulations, Guidelines, and Literature

Regulations governing the program are set forth in 45 CFR Parts 74 and 92 and 40 CFR Part 35. Guidelines are available in the application kit and the PHS Grants Policy Statement No. 90-50,000 (Revised).

Information Contacts

Regional or Local Office

Not applicable.

Headquarters Office

Program Contact: Beth Gardner, Office of Financial and Administrative Services, Agency for Toxic Substances and Disease Registry, 1600 Clifton Road, NE., Mail Stop F-62, Atlanta, GA 30333. Telephone: (770) 488-0572. E-mail address: Programmatic Technical Assistance: David Williamson, Director, Division of Health Studies, Agency for Toxic Substances and Disease Registry, 1600 Clifton Road, NE., Mail Stop F-57, Atlanta, GA 30333. Telephone: (770) 488-0705. Fax: 770-488-7187. E-mail address: Grants Management Contact: Mildred Garner, Acquisition & Assistance Branch, Procurement and Grants Office, Centers for Disease Control and Prevention, 2920 Brandywine road, Room 3000, Atlanta, GA 30341. Telephone: (770) 488-2743. Fax: (770) 488-2745.

Criteria for Selecting Proposals

All applications will be reviewed and evaluated based on the following criteria: l. Appropriateness and knowledge of study design; 2. Proposed study; 3. Relationship to initiative; 4. Quality of data collection; 5. Program personnel; and 6. Program budget (not scored).

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