Great Lakes Human Health Effects Research

To: (1) Build upon and amplify the results from past and on-going research in the Great Lakes basin; (2) develop information, databases and research methodology that will provide long-term benefit to human health effects research in the Great Lakes basin; (3) develop direction for future health effects
research; (4) provide state local health officials: the concerned public and their medical health care professionals; (5) in concert with State and local health offices increase the public awareness regarding the potential health implications of the toxic pollution problem in the Great Lakes basin; and (6) coordinate as necessary with relevant Public Health Service (PHS) research programs and activities, including those of the Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), National Institutes of Health (NIH), and the Indian Health Service (IHS), as well as the Environmental Environment Protection Agency (EPA) and State and local health departments, to ameliorate adverse public health impacts of persistent toxic substances in the Great Lakes basin.
Examples of Funded Projects

(1) The New York State Angler Cohort Study: Exposure Characterization and Reproductive and Developmental Effects; (2) Great Lakes Fish as a Source of Maternal and Fetal Exposure to Chlorinated Hydrocarbons; (3) An Assessment of a Human Population at Risk: The Impact of Consuming Contaminated Great Lakes Fish on Native American Communities; (4) Cognitive and Motor Effects of PCB Exposure in Older People from the Michigan Fish Eaters Cohort: Emphasis on the Role of Ortho-Substituted Congeners; (5) Contribution of Nursing to Behavioral Changes in Offspring of Mothers Who Consumed Lake Ontario Fish: Two Methodological Approaches; (6) Health Risks from Consumption of Great Lakes Fish; and (7) Assessing Effects of Human Reproductive Health of PCB Exposure via Consumption of Great Lakes Fish.

Three grants were awarded to State Health Departments for the following projects: (1) PCB and DDE Exposure among Native American Men from Contaminated Great Lakes Fish and Wildlife; (2) Consortium for the Health Assessment of Great Lakes Sport Fish Consumption; and (3) Michigan Great Lakes Health Studies.

Agency - Department of Health and Human Services

The Department of Health and Human Services is the Federal government's principal agency for protecting the health of all Americans and providing essential human services, especially to those who are least able to help themselves.

Program Accomplishments

In fiscal year 2003, funding was provided for ten competing awards. It is anticipated that there will be ten non-competing continuation awards in fiscal years 2004 and 2005.

Uses and Use Restrictions

To conduct research on the impact on human health of fish consumption in the Great Lakes region.

This Program of Research will focus on populations which have been identified to have a higher risk of long-term adverse health effects from exposure to contaminants in Great Lakes fish, i.e., Native Americans, sport anglers, urban poor, the elderly, Asian Americans, racial/ethnic minority populations, fetuses, and nursing infants of mothers who consume contaminated Great Lakes fish.

Priority areas of research for this program include: 1.

Characterizing exposure and determining the profiles and levels of Great Lakes contaminants in biological tissues and fluids in high-risk populations; 2.

Identifying sensitive and specific human health endpoints, i.e., reproductive/developmental, behavioral, endocrinologic, and immunologic effects and correlating them to exposure to Great Lakes contaminants; and 3.

Determining the short- and long-term risk(s) of adverse health effects in children which result from parental exposure to Great Lakes contaminants.

Proposed projects covering these priority areas should include strategies (risk communication) to inform susceptible populations about the potential human health impact of consuming contaminated fish from the Great Lakes.

Based upon research findings, longer term priority areas may include, but are not limited to: 1.

Investigating the feasibility of, or establishing, registries and/or surveillance cohorts in the Great Lakes region; and 2.

Establishing a chemical mixtures database with emphasis on tissue and blood levels to identify new cohorts, conduct surveillance and health effects studies, and establish registries and/or surveillance cohorts.

Eligibility Requirements

Applicant Eligibility

Eligible applicants are the official public health agencies or their bona fide agents or instrumentalities and political subdivisions thereof, which may include State universities, State colleges, State research institutions, State and local health departments, and federally-recognized Indian tribal governments located in the Great Lakes States.

This includes Illinois, Indiana, Michigan, Minnesota, Ohio, Pennsylvania, New York and Wisconsin and is consistent with Section 106, Subsection 118(e) of the Great Lakes Critical Programs Act of 1990 (33 U.S.C.


Beneficiary Eligibility

Native Americans, Minority Groups, Sport Anglers, Urban Poor, Individuals and Families who consume contaminated Great Lakes Fish.


Costs will be determined in accordance with OMB Circular No. A-87 for State and local governments.

Aplication and Award Process

Preapplication Coordination


An environmental impact statement is not required for this program.

This program is excluded from coverage under E.



Application Procedures

Applicants must use application Form 5161-1. Application packets are available from: Acquisition and Assistance Branch A, Procurement and Grants Office, Centers for Disease Control and Prevention, 2920 Brandywine Road, Room 3000, Atlanta, GA 30341. By formal agreement, the CDC Grants Management Branch will act on behalf of ATSDR on this matter.

Award Procedures

The Assistant Administrator, ATSDR, has final authority to approve funding of applications. When an application is approved for funding, the Grants Management Officer, CDC, acting as agent for ATSDR, will prepare a Notice of Grant Award.


Contact the Headquarters Office identified below for application deadlines.


Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980, as amended; Superfund Amendments and Reauthorization Act of 1986, Sections 104 (i)(5)(A) and (15), Public Law 99-499; 42 U.S.C. 9604 (i)(5)(A) and (15); Great Lakes Critical Programs Act of 1990, Section 106, Subsection 118(e); 33 U.S.C. 1268(e)(3).

Range of Approval/Disapproval Time

Approximately 60 to 90 days.




Awards are made for project periods of one to three years with 12-month budget periods. Renewals awards cannot be made beyond the project period without competition.

Assistance Considerations

Formula and Matching Requirements

This program has no statutory formula or matching requirements.

Length and Time Phasing of Assistance

The awards will be made for 12-month budget periods within a project period of one to three years. Continuation awards within the project period are made on the basis of satisfactory progress and availability of funds.

Post Assistance Requirements


Annual progress and financial status reports are required no later than 90 days after the end of each budget period.

Final financial status and performance reports are required 90 days after the end of the project period.


In accordance with the provisions of OMB Circular No. A- 133 (Revised, June 24, 1997), "Audits of States, Local Governments, and Nonprofit Organizations," nonfederal entities that expend financial assistance of $300,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Nonfederal entities that expend less than $300,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in Circular No. A-133. In addition, grants and cooperative agreements are subject to inspection and audits by HHS and other Federal officials.


Detailed and accurate records of travel expenditures, personnel hours and all other costs will be retained for ten years in accordance with EPA's "Superfund Financial Management and Recordkeeping Guidance for Federal Agencies." Such documents may be required to provide the basis of cost recovery actions or other litigation. Additionally, this documentation must be available for audit or verification upon the request of the Inspector General.

Financial Information

Account Identification



(Grants) FY 07 $1,019,706; FY 08 $1,082,730; and FY 09 est $800,000.

Range and Average of Financial Assistance

$72,000 to $175,000; $119,000.

Regulations, Guidelines, and Literature

Regulations governing this program are set forth in 45 CFR 92 and 40 CFR 35, subpart O. Guidelines are available in the application kit. PHS Grants Policy Statement No. 94-50,000 (Revised) April 1, 1994.

Information Contacts

Regional or Local Office

Not applicable.

Headquarters Office

Program Contact: Dr. Heraline E. Hicks, Division of Toxicology, Agency for Toxic Substances and Disease Registry, 1600 Clifton Road, NE, Mail Stop F-32, Atlanta, Georgia 30333. Telephone: (770) 488-3347. Fax: (770) 488-4178. E-mail address: Grants Management Contact: Mildred Garner, Acquisition and Assistance Branch A, Procurement and Grants Office, Centers for Disease Control and Prevention, 2920 Brandywine Road, Room 3000, Atlanta, GA 30341. Telephone: (770) 488-2745. Fax: (770) 488-2777.

Criteria for Selecting Proposals

Applications will be reviewed and evaluated according to the following criteria: Proposed Program; Program Personnel; Applicant Capability; and Program Budget (Not Scored).

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