Longitudinal Single Cell Characterization of ADRD Postmortem Tissue (R01 Clinical Trial Not Allowed)

This FOA aims to address three major goals.

The first is to utilize single-cell(-nuc) technologies to characterize the changes to cell identity, number, and/or morphology within a defined brain region, the hippocampus, from subjects experiencing mild cognitive impairment (MCI).

Specifically,

credit: Active Rain


applicants will collect single-cell(-nuc) transcriptomic and epigenetic data from neuronal, glial, or vascular cells using MCI autopsy brains.

Next, applicants will propose a data coordination center to collect single-cell(-nuc) omics data generated using diverse tissue sources and various, well-documented tissue preparation techniques from each group in the consortium.

This data will be used to identify critical factors for robust and accurate single-cell(-nuc) omics analysis.

Finally, this FOA will prompt applicants to coordinate their single-cell(-nuc) data sets with those produced by the BRAIN Initiatives human cell census.

The aim is to enable investigators to utilize BRAIN cell census data sets generated from the analysis of healthy human brain and harmonize single-cell(-nuc) data sets from ADRD human brains with the BRAIN Initiative cell type registry.
Related Programs

Aging Research

Department of Health and Human Services


Agency: Department of Health and Human Services

Office: National Institutes of Health

Estimated Funding: $10,000,000





Obtain Full Opportunity Text:
http://grants.nih.gov/grants/guide/pa-files/PAR-22-029.html

Additional Information of Eligibility:
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U. S. Territory or Possession.

Full Opportunity Web Address:
http://grants.nih.gov/grants/guide/pa-files/PAR-22-029.html

Contact:


Agency Email Description:
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

Agency Email:


Date Posted:
2021-09-02

Application Due Date:


Archive Date:
2021-11-10



Pedagogy of the Oppressed, a 1970s book by author Paulo Freire, envisions a world not as a given reality, but as “a problem to be worked on and solved.” That mentality is often applied to the greatest social entrepreneurs.




Not for Profit Jobs in New York

  Program Director Jobs
  Fundraising & Development Jobs
  Foundation Related Jobs
  Program Director Jobs
  Social Services Jobs





More Federal Domestic Assistance Programs


Child and Adult Care Food Program | Professional Exchanges_Annual Open Grant | Early Retiree Reinsurance Program | Small Business Investment Companies | Overseas Refugee Assistance Programs for Western Hemisphere |  Site Style by YAML | Grants.gov | Grants | Grants News | Sitemap | Privacy Policy


Edited by: Michael Saunders

© 2004-2021 Copyright Michael Saunders