This Funding Opportunity Announcement (FOA) invites U24 Cooperative Agreement applications aiming to establish several mis-folded protein polymorphisms resource networks in the area of Alzheimer's disease and its related dementias (AD/ADRD).
The central goal of these resource networks is
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to standardize and distribute seed, oligomers, and fibrils to other investigators in order to clarify and improve the reproducibility of experiments in AD/ADRD.
For the past several years, many studies have developed assays and reagents to understand the biophysical properties of various tau and A structural variants such as oligomers, protofibrils, and fibrils.
As a result, many imaging, chemical, and immunological tools have been developed to detect different types of A and tau polymorphs.
Establishing standards, understanding the pathological roles of these protein polymorphs, and using newly developed analytic tools to address the direct correlation between patient-to-patient variations in A and tau polymorphs are the long-term goals of the resource networks supported by this FOA.