This Funding Opportunity Announcement (FOA) invites applications to establish a network that will conduct transdisciplinary aging diagnostic biomarker and/or imaging research projects focused on Alzheimers Disease and Alzheimers Disease-Related Dementias (AD/ADRD) in persons living with Multiple Chronic
Conditions (MCCs).
The aim of the research is to better align diagnostic testing with the needs and priorities of an aging population.
The national consortium will:
1) assemble existing data and acquire real-world data to ensure that the research sample is large and diverse, with adequate representation of older adults living with well-characterized MCCs, and incorporate pre-specified subgroup analyses; 2) analyze data for performance and accuracy of biomarkers, to include blood, cerebrospinal fluid (CSF), and imaging, in older patients living with MCCs; and 3) conduct pilot studies involving specific AD/ADRD imaging and/or biomarkers in persons living with MCCs.