The Centers for Disease Control and Prevention’s (CDC) National Center for Injury Prevention and Control (NCIPC, Injury Center) is soliciting investigator-initiated research to rigorously evaluate effectiveness of policies for reducing drug use and overdose as well as the effect of these strategies

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on reducing or worsening existing disparities in medical care and health outcomes.

Equally important to quantifying the impacts of these policies on health outcomes is understanding their implementation and how implementation affects achieving the intended outcomes of the policy among groups experiencing disproportionate burden of overdose and/or groups that are at greater risk of experiencing adverse outcomes related to substance use due to social determinants of health.The proposed research should evaluate the impact of a selected local, state, tribal, federal, or organizational policy (e.g., school or health systems) aimed at reducing or regulating substance use or reducing drug overdose, on rates of at least two overdose outcomes (i.e., nonfatal overdose, fatal overdose, substance use disorders, substance use, initiation of substance use among youth).