Development and Validation of Human Cellular Models for Alzheimer's Disease-Related Dementias (ADRD) (R01 - Clinical Trial Not Allowed)

This NOFO would support development and validation of novel clinically- and/or pathophysiologically-relevant human cellular models of ADRD.

The cellular model systems would be expected to capture the multi-faceted pathologies and multiple cell types observed in ADRDs.

Validation includes

credit: Run Luau Run

internal, face, construct, and predictive (to the extent possible) validation.

These models can be developed/validated with the goal of supporting therapy development or better understanding of human disease mechanisms and mechanisms that uncover predisposition to developing neurodegenerative dementias.

Human cellular models need to be novel, complex, and address a gap in the currently available models.

Multidisciplinary teams will be highly encouraged.

Leveraging the use of and depositing new cells into existing NIH cell repository resources will also be encouraged.
Related Programs

Extramural Research Programs in the Neurosciences and Neurological Disorders

Department of Health and Human Services

Aging Research

Department of Health and Human Services

Agency: Department of Health and Human Services

Office: National Institutes of Health

Estimated Funding: $1,500,000

Who's Eligible

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Additional Information of Eligibility:
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U. S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U. S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

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