The FY18 PH/TBIRP CTRR-CTA is intended to support clinical trials focused on TBI cognitive rehabilitation interventions.
The award mechanism supports small, Phase I clinical trials to advance the development of knowledge and materiel products for rehabilitation and restoration of function following
TBI in Service members, Veterans, and other individuals.
Research focusing on rehabilitation strategies in DoD and VA patients with mild TBI with federal rehabilitation research partners is highly encouraged.
The proposed research must be relevant to active duty Service members, Veterans, and their beneficiaries.
It is expected that any research findings will also provide benefit to the general population.
Cognitive rehabilitation-focused clinical trials should generate new knowledge evaluating the effectiveness of novel or standard-of-care rehabilitation interventions in remediating cognitive impairments (e.g., memory, processing speed, executive functioning, new learning, attentional or cognitive communication difficulties) and functional limitations after TBI.
Applications specifically addressing barriers to participation (i.e., return to duty, work, and school) in Service members with TBI are strongly encouraged.
Investigators are encouraged to pursue pragmatic trial designs that compare both novel and standard-of-care cognitive rehabilitation practices, include diverse (but militarily relevant) populations of study participants, recruit patients from heterogeneous practice settings (e.g., DoD and VA), and collect data across a broad range of functioning including standard-of-care DoD outcome measures.