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DoD Scleroderma, Translational Research Partnership Award
The FY21 SRP TRPA mechanism supports partnerships between clinicians, research scientists and other disciplines that will accelerate the movement of promising ideas in scleroderma into clinical applications.
The ultimate goal of translational research is to move a concept or observation forward
into clinical application that is relevant to active-duty Service Members, Veterans, other military beneficiaries, and the American public.
This award supports the development of translational research collaborations between two or more investigators to address a central problem or question in scleroderma in a manner that would be less readily achievable through separate efforts.Observations that drive a research idea may be derived from a laboratory discovery, population-based studies, or clinician’s firsthand knowledge of patients and anecdotal data.
However, members of the partnership should not view translational research as a one-way continuum from bench to bedside.
The research plan must involve a reciprocal flow of ideas and information between basic and clinical science, reflecting an intellectual synergistic partnership between clinicians, research scientists and/or other disciplines.Applicants are encouraged to leverage resources and expertise at the National Center for Advancing Translational Sciences (NCATS) to improve efficiency and accelerate the translational process.
A list of NCATS programs and resources supporting pre-clinical and clinical innovation can be found at https://ncats.nih.gov/research.The FY21 SRP TRPA requires multiple PIs.
At least two, and up to three, PIs must partner in one overarching study.
One partner in the collaboration must be a clinician.
Multi-institutional partnerships are encouraged.
At least one member of the partnership must have experience in either scleroderma research or scleroderma patient care as demonstrated by active funding and/or recent publications.
A proposed project in which the partner merely supplies tissues or access to patients will not meet the intent of this award mechanism.
One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission.
The other PI(s) will be identified as a Partnering PI(s).
All PIs should contribute significantly to the development of the proposed research project, including the Project Narrative, Statement of Work (SOW), and other required components.
If recommended for funding, each PI will be named to an individual award within the recipient organization.
For individual submission requirements for the Initiating and Partnering PIs, refer to Section II.D.2, Content and Form of the Application Submission.
It is the responsibility of the PIs to describe how their combined expertise will better address the research question and explain why the work should be done together rather than through separate efforts.The following are significant features of the FY21 SRP TRPA:• Preliminary Data:
Preliminary data are required but need not be from the scleroderma research field.
Preliminary data may include unpublished or published results from the laboratory of the PIs or collaborators named on the application and/or data from the published literature relevant to scleroderma.• Impact:
The application should describe research that seeks to understand the causes and progression of scleroderma and/or realizing improvements in patient care and/or quality of life with the ultimate goal of accelerating the movement of promising ideas in scleroderma into clinical applications.• Partnership:
The success of the project should depend on the unique skills and contributions of each partner that addresses the research problem through the synergistic backgrounds and scleroderma experience of the PIs.
The success of the project must be supported by the unique skills and contributions of each partner.
The proposed study must include clearly stated plans for interactions between the PIs and institutions involved.
The plans must include communication, coordination of research progress and results, and data transfer.
Additionally, multi-institutional applications must provide an intellectual and material property plan to resolve potential intellectual and material property issues and to remove institutional barriers that might interfere with achieving high levels of cooperation to ensure the successful completion of this award.• Translation:
The application should provide evidence for the reciprocal transfer of information between basic and clinical science, or vice versa, in developing and implementing the research plan.
The application should demonstrate how the study will leverage clinical information to address knowledge gaps, in resulting outcomes, validate key research findings, expand upon potentially transformative results, and/or investigate novel findings.
This mechanism is intended to fund a broad range of translational studies, including, but not limited to, the following:○ Studies advancing/translating in vitro and/or animal research to applications with human samples/cohorts.○ Late-stage preclinical work leading to/preparing for a clinical trial, e.g., Investigational New Drug application submission.○ Correlative studies that are associated with an open/ongoing or completed clinical trial and projects that develop endpoints for clinical trials.○ Animal research must demonstrate potential for translation to patient care.Describe how the research represents more than an incremental advancement in scleroderma research.• Relevance to Military Health:
The SRP seeks to support research that is relevant to the healthcare needs of military Service Members, Veterans, and their families.
Relevance to military health will be considered in determining relevance to the mission of the Defense Health Program (DHP) and FY21 SRP during programmatic review.
Investigators are encouraged to consider the following characteristics as examples of how a project may demonstrate relevance to military health:○ Use of military or Veteran populations, biospecimens, data/databases, or programs in the proposed research○ Collaboration with Department of Defense (DOD) or Department of Veterans Affairs (VA) investigators○ Involvement of military consultants (Army, Air Force) or specialty leaders (Navy, Marine Corps) to the Surgeons General in a relevant specialty area○ Description of how the knowledge, information, products, or technologies gained from the proposed research could be implemented in a dual-use capacity to address a military need that also benefits the civilian population○ Explanation of how the project addresses an aspect of scleroderma that has direct relevance to military Service Members, Veterans, or other Military Health System beneficiaries, including environmental exposuresSubmissions from and partnerships with investigators at DOD military treatment facilities and laboratories, and VA medical centers and research laboratories are encouraged.The proposed research must be relevant to active-duty Service Members, Veterans, military beneficiaries, and/or the American public.The types of awards made under the program announcement will be assistance agreements.
An assistance agreement is appropriate when the federal government transfers a “thing of value” to a “state, local government,” or “other recipient” to carry out a public purpose of support or stimulation authorized by a law of the United States instead of acquiring property or service for the direct benefit and use of the U. S. government.
An assistance agreement can take the form of a grant or cooperative agreement.
The level of involvement on the part of the DOD during project performance is the key factor in determining whether to award a grant or cooperative agreement.
If “no substantial involvement” on the part of the funding agency is anticipated, a grant award will be made (31 USC 6304).
Conversely, if substantial involvement on the part of the funding agency is anticipated, a cooperative agreement will be made (31 USC 6305), and the award will identify the specific substantial involvement.
Substantial involvement may include, but is not limited to, collaboration, participation, or intervention in the research to be performed under the award.
The award type, along with the start date, will be determined during the negotiation process.The anticipated direct costs budgeted for the entire period of performance for an FY21 SRP TRPA will not exceed $750,00 0. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards will be made no later than September 30, 202 2. For additional information refer to Section II.F.1, Federal Award Notices.The CDMRP expects to allot approximately $ 2. 4M to fund approximately two TRPA applications.
Funding of applications received is contingent upon the availability of federal funds for this program as well as the number of applications received, the quality and merit of the applications as evaluated by scientific and programmatic review, and the requirements of the government.
Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds.
It is anticipated that awards made from this FY21 funding opportunity will be funded with FY21 funds, which will expire for use on September 30, 202 7.
The ultimate goal of translational research is to move a concept or observation forward
into clinical application that is relevant to active-duty Service Members, Veterans, other military beneficiaries, and the American public.
This award supports the development of translational research collaborations between two or more investigators to address a central problem or question in scleroderma in a manner that would be less readily achievable through separate efforts.Observations that drive a research idea may be derived from a laboratory discovery, population-based studies, or clinician’s firsthand knowledge of patients and anecdotal data.
However, members of the partnership should not view translational research as a one-way continuum from bench to bedside.
The research plan must involve a reciprocal flow of ideas and information between basic and clinical science, reflecting an intellectual synergistic partnership between clinicians, research scientists and/or other disciplines.Applicants are encouraged to leverage resources and expertise at the National Center for Advancing Translational Sciences (NCATS) to improve efficiency and accelerate the translational process.
A list of NCATS programs and resources supporting pre-clinical and clinical innovation can be found at https://ncats.nih.gov/research.The FY21 SRP TRPA requires multiple PIs.
At least two, and up to three, PIs must partner in one overarching study.
One partner in the collaboration must be a clinician.
Multi-institutional partnerships are encouraged.
At least one member of the partnership must have experience in either scleroderma research or scleroderma patient care as demonstrated by active funding and/or recent publications.
A proposed project in which the partner merely supplies tissues or access to patients will not meet the intent of this award mechanism.
One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission.
The other PI(s) will be identified as a Partnering PI(s).
All PIs should contribute significantly to the development of the proposed research project, including the Project Narrative, Statement of Work (SOW), and other required components.
If recommended for funding, each PI will be named to an individual award within the recipient organization.
For individual submission requirements for the Initiating and Partnering PIs, refer to Section II.D.2, Content and Form of the Application Submission.
It is the responsibility of the PIs to describe how their combined expertise will better address the research question and explain why the work should be done together rather than through separate efforts.The following are significant features of the FY21 SRP TRPA:• Preliminary Data:
Preliminary data are required but need not be from the scleroderma research field.
Preliminary data may include unpublished or published results from the laboratory of the PIs or collaborators named on the application and/or data from the published literature relevant to scleroderma.• Impact:
The application should describe research that seeks to understand the causes and progression of scleroderma and/or realizing improvements in patient care and/or quality of life with the ultimate goal of accelerating the movement of promising ideas in scleroderma into clinical applications.• Partnership:
The success of the project should depend on the unique skills and contributions of each partner that addresses the research problem through the synergistic backgrounds and scleroderma experience of the PIs.
The success of the project must be supported by the unique skills and contributions of each partner.
The proposed study must include clearly stated plans for interactions between the PIs and institutions involved.
The plans must include communication, coordination of research progress and results, and data transfer.
Additionally, multi-institutional applications must provide an intellectual and material property plan to resolve potential intellectual and material property issues and to remove institutional barriers that might interfere with achieving high levels of cooperation to ensure the successful completion of this award.• Translation:
The application should provide evidence for the reciprocal transfer of information between basic and clinical science, or vice versa, in developing and implementing the research plan.
The application should demonstrate how the study will leverage clinical information to address knowledge gaps, in resulting outcomes, validate key research findings, expand upon potentially transformative results, and/or investigate novel findings.
This mechanism is intended to fund a broad range of translational studies, including, but not limited to, the following:○ Studies advancing/translating in vitro and/or animal research to applications with human samples/cohorts.○ Late-stage preclinical work leading to/preparing for a clinical trial, e.g., Investigational New Drug application submission.○ Correlative studies that are associated with an open/ongoing or completed clinical trial and projects that develop endpoints for clinical trials.○ Animal research must demonstrate potential for translation to patient care.Describe how the research represents more than an incremental advancement in scleroderma research.• Relevance to Military Health:
The SRP seeks to support research that is relevant to the healthcare needs of military Service Members, Veterans, and their families.
Relevance to military health will be considered in determining relevance to the mission of the Defense Health Program (DHP) and FY21 SRP during programmatic review.
Investigators are encouraged to consider the following characteristics as examples of how a project may demonstrate relevance to military health:○ Use of military or Veteran populations, biospecimens, data/databases, or programs in the proposed research○ Collaboration with Department of Defense (DOD) or Department of Veterans Affairs (VA) investigators○ Involvement of military consultants (Army, Air Force) or specialty leaders (Navy, Marine Corps) to the Surgeons General in a relevant specialty area○ Description of how the knowledge, information, products, or technologies gained from the proposed research could be implemented in a dual-use capacity to address a military need that also benefits the civilian population○ Explanation of how the project addresses an aspect of scleroderma that has direct relevance to military Service Members, Veterans, or other Military Health System beneficiaries, including environmental exposuresSubmissions from and partnerships with investigators at DOD military treatment facilities and laboratories, and VA medical centers and research laboratories are encouraged.The proposed research must be relevant to active-duty Service Members, Veterans, military beneficiaries, and/or the American public.The types of awards made under the program announcement will be assistance agreements.
An assistance agreement is appropriate when the federal government transfers a “thing of value” to a “state, local government,” or “other recipient” to carry out a public purpose of support or stimulation authorized by a law of the United States instead of acquiring property or service for the direct benefit and use of the U. S. government.
An assistance agreement can take the form of a grant or cooperative agreement.
The level of involvement on the part of the DOD during project performance is the key factor in determining whether to award a grant or cooperative agreement.
If “no substantial involvement” on the part of the funding agency is anticipated, a grant award will be made (31 USC 6304).
Conversely, if substantial involvement on the part of the funding agency is anticipated, a cooperative agreement will be made (31 USC 6305), and the award will identify the specific substantial involvement.
Substantial involvement may include, but is not limited to, collaboration, participation, or intervention in the research to be performed under the award.
The award type, along with the start date, will be determined during the negotiation process.The anticipated direct costs budgeted for the entire period of performance for an FY21 SRP TRPA will not exceed $750,00 0. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards will be made no later than September 30, 202 2. For additional information refer to Section II.F.1, Federal Award Notices.The CDMRP expects to allot approximately $ 2. 4M to fund approximately two TRPA applications.
Funding of applications received is contingent upon the availability of federal funds for this program as well as the number of applications received, the quality and merit of the applications as evaluated by scientific and programmatic review, and the requirements of the government.
Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds.
It is anticipated that awards made from this FY21 funding opportunity will be funded with FY21 funds, which will expire for use on September 30, 202 7.
Who's Eligible
Relevant Nonprofit Program Categories
Obtain Full Opportunity Text:
https://bja.ojp.gov/funding/opportunities/o-bja-2021-111001
Additional Information of Eligibility:
State, local, and tribal law enforcement and prosecution agencies For purposes of this solicitation, "state" means any state of the United States, the District of Columbia, the Commonwealth of Puerto Rico, the Virgin Islands, Guam, American Samoa, and the Commonwealth of the Northern Mariana Islands.
Tribal law enforcement and prosecution agencies must be from federally recognized Indian tribal governments that perform law enforcement functions (as determined by the Secretary of the Interior).
To advance Executive Order 13929 Safe Policing for Safe Communities, as of October 28, 2020, the Attorney General determined that all state, local, and university or college law enforcement agencies must be certified by an approved independent credentialing body or have started the certification process to be allocated FY 2021 DOJ discretionary grant funding, as either a recipient or a subrecipient.
For detailed information on this new certification requirement, please visit https://cops.usdoj.gov/SafePolicingEO.
To ensure a comprehensive approach, applicants must outline their plan to collaborate with key partners.
Applicants can address this with existing strategies or create task forces and/or partnerships with other agencies and nonprofit organizations with expertise to implement a comprehensive program including outreach, education, investigation, and prosecution of hate crimes.
All recipients and subrecipients (including any for-profit organization) must forgo any profit or management fee.
Full Opportunity Web Address:
https://bja.ojp.gov/funding/opportunities/o-bja-2021-111001
Contact:
Agency Email Description:
CDMRP Help Desk
Agency Email:
Date Posted:
2021-05-14
Application Due Date:
Archive Date:
2021-09-24
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