Trans-NIH Research Support

To provide support for new initiatives designed to address major opportunities and gaps in biomedical research that no single NIH institute could address alone, but which the agency as a whole can pursue to stimulate the progress of biomedical research and to catalyze changes that will serve to transform

credit: Care2
new scientific knowledge into tangible benefits for public health.

Information on recent and current initiatives is available at at .
Examples of Funded Projects

FY 2004 was the first year of the Roadmap program.

Awards were made for health-related research projects that pertain to the mission of the Roadmap.

Lists of the awards made in FY 2004 and FY 2005 are available at

Agency - Department of Health and Human Services

The Department of Health and Human Services is the Federal government's principal agency for protecting the health of all Americans and providing essential human services, especially to those who are least able to help themselves.

Office - Financial or Grants Management contact as provided on the initiative, or Director, Office of Policy for Extramural Research Administration (OPERA), OER, NIH for award policy or application issues: 301-435-0938.

Relevant Nonprofit Program Categories

Selected Recipients for this Program

RecipientAmount Start DateEnd Date
Dana-farber Cancer Institute, Inc. $ 182,969,921   1977-12-012026-11-30
Washington University, The $ 1,102,500   2021-09-302026-08-31
University Of Pittsburgh, The $ 1,817,770   2021-09-292026-08-31
Emory University $ 368,128   2021-09-232026-08-31
Weill Medical College Of Cornell University $ 613,724   2021-09-202026-08-31
University Of Texas Southwestern Medical Center, The $ 830,576   2021-09-272026-08-31
Rector & Visitors Of The University Of Virginia $ 452,561   2021-09-012026-08-31
Wayne State University $ 694,650   2021-09-222026-08-31
Florida State University $ 1,428,921   2021-09-102026-08-31
Yale University $ 1,172,500   2021-09-302026-08-31

Program Accomplishments

IN FY 2004 and FY 2005, awards were made to support research projects that accelerate fundamental discovery and translation of that knowledge into effective prevention strategies and new treatments that will lead to better health for U.S. citizens. Lists of the awards that were made are available on the NIH Roadmap web site, at

Uses and Use Restrictions

To support research and other projects that will accelerate fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments.

Eligibility Requirements

Applicant Eligibility

Awards can be made to domestic, public or private, for-profit or nonprofit organization, university, college, hospital, laboratory, or other institution, including State and local units of government, and individuals.

Some initiatives will accept applications from foreign organizations.

Additional details on eligibility are specified in the Roadmap Grants and Funding Opportunities funding announcement, listed at .

Beneficiary Eligibility

Institutions as described above.


Applications must be submitted in compliance with instructions provided with each initiative.

Aplication and Award Process

Preapplication Coordination


This program is excluded from coverage under E.O.


Application Procedures

Prepare and submit applications according to instructions provided in the applicable Roadmap Grants and Funding Opportunities announcement, located at . This program is subject to the provisions of 45 CFR 74 including applicable federal cost principles as referenced, the NIH Grants Policy Statement (rev. 11/2003), and the provisions in the funding announcement. NIH is transitioning to an electronic application by grant mechanism. Details, including the appropriate application form, can be found at

Award Procedures

Applications are reviewed for scientific and technical merit by a scientific review group and for program relevance by a national advisory council/board.


Application deadlines are specified in the Roadmap Grants and Funding Opportunities funding announcement, listed at .


Public Health Service Act, Title IV, Section 301, as amended.

Range of Approval/Disapproval Time

The length of the review cycle is four to nine months.


A principal investigator may question the substantive or procedural aspects of the review of his/her application by communicating with the NIH Scientific/Research contact, as provided on an initiative. A description of the NIH Peer Review Appeal procedures is available on the NIH Web site at .


Renewal (competing continuation, type 2) applications to Roadmap programs are not accepted unless specifically accepted by NIH staff.

Assistance Considerations

Formula and Matching Requirements

This program has no statutory formula or matching requirements.

Length and Time Phasing of Assistance

Almost all awards are made for at least one year, with additional support (up to four more years) depending on the recommendation of the scientific review group, the national advisory council, successful annual performance, and availability of funds.

Post Assistance Requirements


Annual progress reports and selected financial reports are required for continuing projects.

Final progress reports, invention statements, and expenditure reports are required at the end of the projects.


In accordance with the provisions of OMB Circular No. A-133 (Revised, June 27, 2003), "Audits of States, Local Governments, and Nonprofit Organizations," nonfederal entities that expend financial assistance of $500,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Nonfederal entities that expend less than $500,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in Circular No. A-133. In addition, grants and cooperative agreements are subject to inspection and audits by DHHS and other Federal government officials.


Expenditures and other financial records, and also administrative records, must be retained for 3 years from the day on which the grantee submits the last expenditure report for the grant period.

Financial Information

Account Identification



(Grants) FY 07 $353,000,000; FY 08 est not available; and FY 09 est not reported.

Range and Average of Financial Assistance

$2,300 to $3,800,000; $620,000.

Regulations, Guidelines, and Literature

45 CFR 74; 42 CFR 52. NIH Grants Policy Statement, (Rev.) December 1, 2003. The PHS 398 may be obtained from NIH's Extramural Research Home Page:

Information Contacts

Regional or Local Office

Financial or Grants Management contact as provided on the initiative, or Director, Office of Policy for Extramural Research Administration (OPERA), OER, NIH for award policy or application issues: 301-435-0938.

Headquarters Office

Scientific/Research contact as provided on an initiative or Program Director, Office of Extramural Programs (OEP) for questions on program administration, 301-435-2690. Dr. Lisa Colpe, Acting Assistant Director for Roadmap Coordination, Office of the Director, National Institutes of Health, Bethesda, MD 20892; 301-402-7617.

Criteria for Selecting Proposals

Funding decisions are based on scientific merit (42 CFR 52h) and program relevance. Scientific merit review encompasses: the peer review criteria detailed in the specific funding announcement, as well as the significance, approach, and innovation of the proposed research; the competency of the principal investigator; the adequacy of the resources and environment; the proposed budget and requested period of support; and, where applicable, the adequacy of the measures for protecting against adverse effects upon humans, animals, or the environment.

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