HEAL Initiative: HEAL Data2Action Acceleration Projects (R33 Clinical Trial Not Allowed)

As part of the NIH HEAL Initiative, the National Institute on Drug Abuse (NIDA) is releasing a set of interrelated FOAs to create the HEAL Data2Action (HD2A) Program, a coordinated effort to promote the synthesis and real-world application of existing data to improve epidemiology and guide and monitor

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improvements in service delivery to prevent or treat opioid use disorder (OUD) and pain.

Collectively, these projects will improve the quality, timeliness, accessibility and usefulness of data for epidemiology and service delivery in each of the four pillars of the HHS Overdose Prevention Strategy:
primary prevention, harm reduction, treatment of opioid use disorder, and recovery support.

Separate FOAs have been issued to support multiple HD2A Innovation Projects (RFA-DA-22-051); one HD2A Data Infrastructure Support Center (RFA-DA-22-052); one HD2A Research Adoption Support Center (RFA-DA-22-050); and one HD2A Economics and Modeling Resource Center (RFA-DA-22-049).

It is imperative that prospective applicants read all of these related RFAs to better understand the intended purpose and structure of the HD2A Program.

This FOA solicits applications for HEAL Data2Action (HD2A) Acceleration Projects.

Research Projects will focus on developing data or methods that improves timeliness, quality, accessibility, or usefulness of existing data ecosystems to allow for faster and improved responses and allocation of resources to address the overdose crisis.

This FOA invites projects for which preliminary or feasibility data are available, such as from an R21 study or its equivalent.

This FOA is a companion to RFA-DA-232-057, which solicits Acceleration and Innovation Project applications for which pilot data are unavailable.
Related Programs

Drug Abuse and Addiction Research Programs

Department of Health and Human Services

Who's Eligible

Obtain Full Opportunity Text:

Additional Information of Eligibility:
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U. S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.

Non-domestic (non-U.S.) components of U. S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Full Opportunity Web Address:


Agency Email Description:
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

Agency Email:

Date Posted:

Application Due Date:

Archive Date:

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