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DoD Breast Cancer, Breakthrough Award Levels 1 and 2
The intent of the Breakthrough Award is to support promising research that has high potential to lead to or make breakthroughs in breast cancer.
The critical components of this award mechanism are:
Impact:
Research supported by the Breakthrough Award will have the potential for a major impact
and accelerate progress toward ending breast cancer.
The impact may be near-term or long-term, but must move beyond a minor advancement and have the potential to lead to a new approach that is fundamentally better than interventions already approved or in clinical development.
Applications are expected to identify the breast cancer patients or at-risk individuals who would ultimately benefit from the proposed research.
Research Scope:
The Breakthrough Award is structured with four different funding levels.
The levels are designed to support major (but not all) stages of research that will lead to clinical application.
Each level has a defined research scope.
It is the responsibility of the Principal Investigator (PI) to select the level that aligns with the scope of the proposed research.
The funding level should be selected based on the research scope defined in the Program Announcement, and not on the amount of the budget.
The Government reserves the right to fund an application at a lower funding level.
The current Program Announcement discusses the Breakthrough Award Levels 1 and 2. Funding Levels 3 and 4 are available under other Program Announcements (W81XWH-20- BCRP-BTA3 and W81XWH-20-BCRP-BTA4, respectively).
The PI is strongly encouraged to review the research scope defined under each funding level as described in the corresponding Breakthrough Award Program Announcement before submitting the pre-application.
The following are general descriptions, although not all-inclusive, of the scope of research projects that would be appropriate to propose under the current Program Announcement:
Funding Level 1:
Innovative, high-risk/high-reward research that is in the earliest stages of idea development or is an untested theory that addresses an important problem.
To foster research that yields new avenues of investigation, preliminary data are not required.
Proof of concept is the anticipated outcome.
Funding Level 2:
Preclinical research that is already supported by substantial preliminary or published data and strongly validates clinical translation in a well-defined context within the breast cancer landscape.
Funding Level 2:
Population Science and Prevention Studies:
Preclinical research that is already supported by substantial preliminary or published data and strongly validates clinical translation in a well-defined context within the breast cancer landscape.
With compelling justification, population science and prevention studies may request higher levels of funding and an additional year in the period of performance.
Such studies may require additional resources due to the participation of human subjects and/or use of human biospecimens.
Partnering PI Option:
The Breakthrough Award encourages applications that include meaningful and productive collaborations between investigators.
The Partnering PI Option is structured to accommodate two PIs.
One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission.
The other PI will be identified as a Partnering PI.
Initiating and Partnering PIs each have different submission requirements, as described in Section II.D.2, Content and Form of the Application Submission; however, both PIs should contribute significantly to the development of the proposed research project including the Project Narrative, Statement of Work (SOW), and other required components.
If recommended for funding, each PI will be named to an individual award within the recipient organization.
The PIs may have expertise in similar or disparate scientific disciplines, but each PI is expected to bring distinct contributions to the application.
New collaborations are encouraged, but not required.
The application is expected to describe how the PIs’ combined expertise will better address the research question and explain why the work should be done together rather than through separate efforts.
To meet the intent of the Partnering PI Option, applicants are discouraged from being named as a Partnering PI on multiple Breakthrough Award Levels 1 and 2 applications unless they are clearly addressing distinct research questions.
Applications in which a mentor and their current postdoctoral fellow or junior investigator are named as Initiating and Partnering PIs do not meet the intent of the Partnering PI Option.
Personnel:
Applications are expected to include an appropriate and robust research team with the combined backgrounds and breast cancer-related expertise to enable successful conduct of the project.
The critical components of this award mechanism are:
Impact:
Research supported by the Breakthrough Award will have the potential for a major impact
and accelerate progress toward ending breast cancer.
The impact may be near-term or long-term, but must move beyond a minor advancement and have the potential to lead to a new approach that is fundamentally better than interventions already approved or in clinical development.
Applications are expected to identify the breast cancer patients or at-risk individuals who would ultimately benefit from the proposed research.
Research Scope:
The Breakthrough Award is structured with four different funding levels.
The levels are designed to support major (but not all) stages of research that will lead to clinical application.
Each level has a defined research scope.
It is the responsibility of the Principal Investigator (PI) to select the level that aligns with the scope of the proposed research.
The funding level should be selected based on the research scope defined in the Program Announcement, and not on the amount of the budget.
The Government reserves the right to fund an application at a lower funding level.
The current Program Announcement discusses the Breakthrough Award Levels 1 and 2. Funding Levels 3 and 4 are available under other Program Announcements (W81XWH-20- BCRP-BTA3 and W81XWH-20-BCRP-BTA4, respectively).
The PI is strongly encouraged to review the research scope defined under each funding level as described in the corresponding Breakthrough Award Program Announcement before submitting the pre-application.
The following are general descriptions, although not all-inclusive, of the scope of research projects that would be appropriate to propose under the current Program Announcement:
Funding Level 1:
Innovative, high-risk/high-reward research that is in the earliest stages of idea development or is an untested theory that addresses an important problem.
To foster research that yields new avenues of investigation, preliminary data are not required.
Proof of concept is the anticipated outcome.
Funding Level 2:
Preclinical research that is already supported by substantial preliminary or published data and strongly validates clinical translation in a well-defined context within the breast cancer landscape.
Funding Level 2:
Population Science and Prevention Studies:
Preclinical research that is already supported by substantial preliminary or published data and strongly validates clinical translation in a well-defined context within the breast cancer landscape.
With compelling justification, population science and prevention studies may request higher levels of funding and an additional year in the period of performance.
Such studies may require additional resources due to the participation of human subjects and/or use of human biospecimens.
Partnering PI Option:
The Breakthrough Award encourages applications that include meaningful and productive collaborations between investigators.
The Partnering PI Option is structured to accommodate two PIs.
One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission.
The other PI will be identified as a Partnering PI.
Initiating and Partnering PIs each have different submission requirements, as described in Section II.D.2, Content and Form of the Application Submission; however, both PIs should contribute significantly to the development of the proposed research project including the Project Narrative, Statement of Work (SOW), and other required components.
If recommended for funding, each PI will be named to an individual award within the recipient organization.
The PIs may have expertise in similar or disparate scientific disciplines, but each PI is expected to bring distinct contributions to the application.
New collaborations are encouraged, but not required.
The application is expected to describe how the PIs’ combined expertise will better address the research question and explain why the work should be done together rather than through separate efforts.
To meet the intent of the Partnering PI Option, applicants are discouraged from being named as a Partnering PI on multiple Breakthrough Award Levels 1 and 2 applications unless they are clearly addressing distinct research questions.
Applications in which a mentor and their current postdoctoral fellow or junior investigator are named as Initiating and Partnering PIs do not meet the intent of the Partnering PI Option.
Personnel:
Applications are expected to include an appropriate and robust research team with the combined backgrounds and breast cancer-related expertise to enable successful conduct of the project.
Who's Eligible
Relevant Nonprofit Program Categories
Obtain Full Opportunity Text:
MTO Solicitations page
Additional Information of Eligibility:
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U. S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U. S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Full Opportunity Web Address:
http://www.darpa.mil/Opportunities/Solicitations/MTO_Solicitations.aspx
Contact:
Agency Email Description:
CDMRP Help Desk
Agency Email:
Date Posted:
2019-12-23
Application Due Date:
Archive Date:
2020-04-25
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