Purpose.

This AHRQ FOA, supported by funds provided to AHRQ under the American Recovery and Reinvestment Act of 2009 (Recovery Act or ARRA), Public Law 111-5, invites Exploratory/Developmental grant (R21) applications from organizations that aim to understand the comparative value of different

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strategies in the prevention and management of chronic illness in persons with specific constellations of co-morbid conditions.

Exploratory research studies will contribute evidence to help guide the appropriate integration (i.e., prioritization, timing, provision and coordination) of therapeutic and preventive services in individuals with multiple chronic conditions.

This work should improve our understanding of the comparative value of interventions to patients with multiple conditions, how the safety and effectiveness of specific interventions may be affected by co-morbid conditions, and how interventions may need to be modified for specific patient populations with multiple conditions.

This information should help clinicians better integrate care provided to such individuals, help patients make informed decisions about health care choices, and help policymakers identify better ways to measure and promote quality care for complex patients.