The LRP Impact Award mechanism is being offered for the first time in FY1 7. The LRP Impact Award encourages applications that support the full spectrum of research projects or ideas that specifically focus on scientific and clinical lupus issues, which, if successfully addressed, have the potential

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to make a major impact in lupus research.

Applications should include a well-formulated, testable hypothesis based on strong scientific rationale that is established through inferential reasoning and/or critical review and analysis of the literature.

Inclusion of preliminary data is encouraged.

The following are important aspects of the Impact Award:
• Impact:
The proposed research should impact an area of paramount importance in lupus disease.

It is the responsibility of the Principal Investigator (PI) to clearly and explicitly describe the potential impacts of the proposed study on lupus and to convey its level of significance.

• Research Strategy:
The scientific rationale and experimental methodology should demonstrate critical understanding and in-depth analysis of lupus.

Experimental strategies may be novel or may be based on strong rationale derived from a literature review.

• Preliminary Data:
Inclusion of preliminary data, such as unpublished data from the laboratory of the PI and/or data from published literature that are relevant to lupus and support the proposed research project, is encouraged, but not required.

• Focus Areas:
The proposed research must address at least one of the FY17 LRP Focus Areas.

Clinical trials are not allowed under this Program Announcement.