NIH Health Care Systems Research Collaboratory - Pragmatic and Implementation Trials of Embedded Interventions (UG3/UH3, Clinical Trials Optional)

This Funding Opportunity Announcement (FOA) encourages UG3/UH3 phased cooperative research applications to conduct efficient, large-scale pragmatic trials or implementation studies that focus on improving health outcomes for underserved US patient populations.

Awards made under this FOA will initially

credit: Care2

support a one-year milestone-driven planning phase (UG3), with possible transition to an implementation phase (UH3).

UG3 projects that have met the scientific milestone and feasibility requirements may transition to the UH3 phase.

The UG3/UH3 application must be submitted as a single application, following the instructions described in this FOA.

The overall goal of this initiative is to support the "real world" assessment of health care strategies and clinical practices and procedures in health care systems (HCS) that lead to improved care for underserved populations; who have suffered a disproportionate disease burden in the US.

Results from the pragmatic studies supported by this FOA should inform policy makers, payers, doctors and patients across diverse patient care settings.

This FOA requires that the intervention under study be embedded into health care delivery system, real world settings.

Studies can propose to integrate multi-modal or multiple interventions that have demonstrated efficacy into HCS; or implement HCS changes to improve adherence to evidence-based guidelines.

Trials or studies should be conducted across three or more health care systems (HCS) that provide care to underserved patient populations; and will become part of and work with the NIH HCS Research Collaboratory.

The NIH HCS Research Collaboratory Program has established a Collaboratory Coordinating Center (CCC) that is providing national leadership and technical expertise in all aspects of research with HCS (See Companion FOA).
Related Programs

Aging Research

Department of Health and Human Services

Obtain Full Opportunity Text:

Additional Information of Eligibility:
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U. S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.

Non-domestic (non-U.S.) components of U. S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Full Opportunity Web Address:


Agency Email Description:
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

Agency Email:

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