Recent advances in medical and healthcare technologies are creating a paradigm shift in how medical practitioners and biomedical researchers approach the diagnosis, prevention, and treatment of diseases.

New imaging technologies, advances in genetic testing, and innovations in wearable and/or

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ambient sensors are allowing researchers to predict health outcomes and develop personalized treatments or interventions.

Coupled with the rapid growth in computing and infrastructure, researchers now have the ability to collect, store, and analyze vast amounts of health- and disease-related data from biological, biomedical, behavioral, social, environmental, and clinical studies.

The explosion in the availability of biomedical big data from disparate sources, and the complex data structures including images, networks, and graphs, pose significant challenges in terms of visualization, modeling, and analysis.

While there have been some encouraging developments related to foundational mathematical, statistical, and computational approaches for big data challenges over the past decade, there have been relatively few opportunities for collaboration on challenges related to biomedical data science.

The National Science Foundation (NSF) and the National Institutes of Health (NIH) recognize that fundamental questions in basic, clinical, and translational research could benefit greatly from multidisciplinary approaches that involve experts in quantitative disciplines such as mathematics, statistics, and computer science.

The Quantitative Approaches to Biomedical Big Data Program is designed to support research that addresses important application areas at the intersection of the biomedical and data sciences by encouraging inter- and multi-disciplinary collaborations that focus on innovative and transformative approaches to address these challenges.